AN
ARTICLE ON THERAPY

This
worksheet should be submitted along with the completed Submission Form to your
supervisor. It is based on the articles on therapy from the JAMA series on
Users’ Guides to the Medical Literature. Reading these articles should be
helpful to you in working through this worksheet as it pertains to your key
article(s). Feel free to make

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photocopies.
You can also print off additional copies from the CFPC Web Site (www.cfpc.ca/cme/pearls/pearlsmain.asp
).

 

Author(s):

Short title:

Journal/Year/Volume/
Pages:

 

A.
ARE THE STUDY RESULTS VALID?

1. Was the assignment
of patients to treatment groups truly randomized?

Yes

No

Can’t tell

 

2. Were all patients
who entered the study accounted for appropriately at the end?

i) Is the number
randomized the same as in results? (Try a best case/ worse case scenario.)

ii) Were patients
analysed in the groups they were allocated to at the start of the study?

Yes

No

Can’t tell

 

3. Were patients,
physicians, and those doing the assessments “blind” to treatment?

Yes

No

Can’t tell

 

4. Was similarity
between groups documented?

i) Is there a table of
baseline characteristics?

ii) Were differences
controlled for in the analysis?

Yes

No

Can’t tell

 

5. Aside from the
intervention, were the groups treated in the same way?

Yes

No

Can’t tell

 

B.
WHAT WERE THE RESULTS?

1. How large was the
treatment effect?

2. How precise was
the estimate of the treatment effect?

 

C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?

1. Can the results be
applied to my patient (care)?

i) Are study patients
similar to your patient?

Yes

No

Can’t tell

 

2. Were all
clinically important outcomes reported?

i) Were the most
important outcomes used?

ii) Were quality of
life outcomes used? Assessment of adverse effects?

Yes

No

Can’t tell

 

3. Are the likely
treatment benefits greater than the potential harms and costs? Yes

No

Can’t tell

 

CONCLUSIONS

 

 

The
results or recommendations are valid (from A).

Yes

 No

Can’t tell

 

The
results are clinically important (from B).

Yes

No

Can’t tell

 

The results are relevant to
my practice (from C).

Yes

 No

 Can’t tell