preparation
of inclusion complexes of substituted 4-Thiazolidinone derivatives with
?-cyclodextrin is the objective of our experiment .The inclusion complex  prepared in order to increase solubility and
bio-accessibility of the parent compound. 2-Hydrazinobenzothiazole  is taken as a starting material to carry out
the experiment and A series of compounds and their inclusion is prepared from it.
The formation of compounds and their inclusion complex are established by Analyzing  their physical, thermal and spectral  characteristics (UV,IR,NMR),  Except this, stability constant and free
energy change of both the compound and inclusion complex justify its formation.
Their antibacterial study  helps to know
that ,the inclusion complex has shown better behavior as compared to their
originated compound.

       Key words:
4-Thiazolidinone; inclusion complexes; Spectral characteristics ; Antibacterial
activity.

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 INTRODUCTION

  
         Objective of  the organic and medicinal chemistry is to Design
and synthesis of high therauptic value of compound. In this end, Heterocyclic
compounds containing nitrogen and sulphur has a vast significance in pharmaceutical
and medicinal chemistry. A large number of pharmacologist and chemists worked
on condensed 4-Thiazolidinone due to their significant theruptic and other
biological properties. As a result there is a wide application of
4-Thiazolidinone. Different substituted 4-thiazolidinone has been found to be
possessed diverse type of activities like                         antimicrobial 1-2,antioxidant3, anti-HIV4,
antihistaminic5, anti-convulsant6-7, anti-inflammatory8-10.  In the present work, 2-hydrazinobenzothiazoles
is taken as starting material, four compounds has been prepared from it. Since
the compounds has poor solubility ,hence they can not provide maximum
bio-accessibility .So our objective is to develop a supramolecule by combining
organic compound with  ?-cyclodextrin. Different
concentration of ?-cyclodextrin has been taken with the compound solution to
know the best encapsulation of the compound.   Easy
avaibality , less-toxicity and cost effective nature of ?-cyclodextrin in
nature are some of the prime nature  for
popularity of it11-13.  Inclusion
complexes are prepared by encapsulating the synthesized 2- phenyl- (3-Benzothiazolyl-2′)amino-5-benzylidiene-4-thiazolidinone derivatives with ?-cyclodextrin. The
compound and their inclusion complexes are tested for their physical, thermal
and spectral characteristics. The thermodynamic stability constants and the
free energy change of the inclusion complexes are determined.  The Antibacterial  tests of compounds and their inclusion has
been done.   

                                            

 

                                                           
EXPERIMENTAL

Apparatus and Materials:

                
All the chemicals used during the
present work are procured with analytical reagent grade and purchased from Himedia Laboratories
Pvt. Limited, Mumbai ,India .  In the laboratory Double distilled water was
prepared and it is used as the solvent for dilution purpose.  The electronic spectra were recorded on
Shimadzu UV-1700 Spectrophotometer while IR-spectra were recorded in KBr
pellets in 400-4000 cm-1 region on a Shimadzu 8400 FTIR Spectrophotometer.
1H
NMR  spectra (CDCl3) are
scanned  on a DRX-300 (300MHz)
spectrophotometer using TMS as internal standard and chemical shifts are
expressed in ? scale. Purity of synthesized compounds has been checked by sulphur
detection and homogeneity has been checked by TLC using silica gel. Open capillary
method   was used to know the melting point of the
compounds and are uncorrected.  

Synthesis of
compounds

The compounds were synthesized as per the method
describe by Garnaik et.al 14scheme-I